Dana-Farber Cancer Institute
Stephanie Dougan is an Associate Professor of Cancer Immunology and Virology at Dana-Farber Cancer Institute and an Associate Professor of Immunology at Harvard Medical School. She received her PhD in Immunology from Harvard University where she studied lipid antigen presentation. She performed a postdoctoral fellowship with Hidde Ploegh at Whitehead Institute, where she became adept in somatic cell nuclear transfer and embryo manipulations for the purpose of generating transnuclear and CRISPR genome-modified mice. Dr. Dougan joined the faculty at Harvard Medical School and Dana-Farber Cancer Institute in 2014, where her lab uses unique mouse models to study the immune response to tumors such as pancreatic cancer that do not induce a CD8 T cell response at baseline. The Dougan lab has investigated multiple treatment modalities for augmenting T cell responses in pancreatic cancer, including targeted cytokine delivery and anti-CD40 and radiation. Although she started with the assumption that T cells killed tumor cells directly, her lab has discovered that modulation of non-canonical NF-kB signaling with IAP antagonists induces a T cell dependent activation of macrophages, resulting in phagocytosis of live tumor cells. She collaborates with basic and clinical faculty through the DFCI Hale Center for Pancreatic Cancer Research to work on advancing new therapeutics for patients with pancreatic cancer. Dr. Dougan is a Pew-Stewart Scholar in Cancer Research, a Bill and Melinda Gates Global Health Innovation Scholar, a Melanoma Research Alliance Young Investigator, and received a Pathway to Leadership Award from the Pancreatic Cancer Action Network and AACR. She has continued to work with the Pancreatic Cancer Action Network on the Precision Promise trial. She is also dedicated to training young scientists and received a Young Mentor Award from Harvard Medical School in 2019. She is the Director of the Harvard Immunology Summer Undergraduate Research Program and the course director for AISC Immunology at Harvard Medical School.
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Cancer Immunity & Immunotherapy Course (Separate Registration Required)
Tuesday, June 24, 2025
8:00am - 5:15pm East Coast USA Time
