Associate Member, Human Oncology Pathogenesis Program and Adult BMT Service
Memorial Sloan Kettering Cancer Center
Alan Hanash earned his undergraduate degree from the University of Michigan before completing both his M.D. and Ph.D. at the University of Miami, where he studied transplant immunology under Robert Levy. He then trained in internal medicine at the University of Chicago and completed a fellowship in medical oncology at Memorial Sloan Kettering Cancer Center (MSKCC), where he worked with Marcel van den Brink on cytokine responses in experimental bone marrow transplantation (BMT). Dr. Hanash is now an attending physician on the Adult BMT Service at MSKCC. His laboratory focuses on transplant immunology, specifically how innate and adaptive immune responses affect the intestinal epithelium. His research has shown that donor T cells can target the intestinal stem cell compartment following BMT. In contrast, Interleukin-22 (IL-22), produced by innate lymphoid cells, helps protect these stem cells and supports epithelial regeneration. This foundational work paved the way for a multi-center clinical trial testing a novel recombinant human IL-22 dimer in transplant patients. The goal of this trial is to enhance intestinal recovery and reduce the severity of graft-versus-host disease.
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Immune-mediated Regulation of the Intestinal Stem Cell Compartment
Wednesday, June 25, 2025
9:00am - 9:30am East Coast USA Time
