Assistant Professor of Medicine
Massachusetts General Hospital, Harvard Medical School, Broad Institute
Alexandra-Chloé Villani is a Principal Investigator at the Massachusetts General Hospital (MGH) Krantz Family Center for Cancer Research and at the Center for Immunology and Inflammatory Diseases, where she is also the Director of the Single Cell Genomics Research Program. She is an Institute member of Broad Institute of MIT and Harvard, and an Assistant Professor of Medicine at Harvard Medical School.
The Villani Lab aims at achieving a higher resolution definition and functional characterization of cell subsets and rules governing human immune response regulation as a foundation for deciphering how immunity is dysregulated in diseases. They are using single-cell ‘multi-omics’ and systems immunology strategies empowering the modeling of the human immune system as a function of “healthy” and inflammatory states, disease progression, and response to treatment. Villani currently co-leads a multi-disciplinary team of 24 scientists and 62 clinicians at the MGH working towards achieving a better understanding of the biological players driving immune-related adverse events induced by immune-checkpoint inhibitor therapy. Their goal is to improve cancer patient care through novel biomarker and therapeutic targets identification that could mitigate irAE without reducing the efficacy of the immunotherapy. The Villani Lab is also charting at high-resolution the immune circulating cellular landscape across 40 immune-related diseases with the goal of creating a thorough reference map and establishing how circulating immune cells mirror those in tissue in health and diseases. Altogether, Villani’s work seeks to develop a more comprehensive human immune lexicon that will be key to promoting effective bench-to-bedside translation of findings.
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Checkpoint Myocarditis: Bridging Clinical Challenges and Translational Discoveries
Wednesday, June 25, 2025
11:00am - 11:30am East Coast USA Time
