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Session: Immune Dysregulation, Lessons from Monogenic Disease
Golgi-trapped TNFRSF1A Variants Induce Endosomal Dysfunction and Stress-driven Inflammation in Still’s Disease
Thursday, June 26, 2025
2:10pm - 2:35pm
East Coast USA Time
Location: Salons A-D
Speaker(s)
Michael Ombrello, MD
Tenure Track Investigator
NIAMS/NIH
Disclosure(s):
Michael Ombrello, MD
: No financial relationships to disclose
Learning Objectives:
Describe the relationship betwen TNFR1 loss of function variation and Still's disease.
Contrast the mislocalization of TNFR1-TRAPS variants with TNFR1-Still's varants.
Describe how TNFR1 variants can drive cellular stress can lead to inflammation in Still's disease.
