W116 - Health-related Quality of Life in 85 Children with Primary Antibody Deficiencies in Mainland China: A Prospective Cohort Study

Abstract Text: Objective
The health-related quality of life (HRQoL) and treatment status of children with Primary antibody deficiencies (PADs) in mainland China remain under-researched. This study aims to assess the HRQoL of these children and identify associated factors.
Method
A prospective cohort study was conducted on children diagnosed with PAD and receiving medical care at our center from December 2017 to November 2022. Data were collected using demographic and treatment status questionnaires and the Parent-proxy Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scale.
Results
A total of 85 PAD patients were included, with a mean age of 9.2 years (SD: 4.3); 79 (92.9%) were male, and 6 (7.1%) were female. Good treatment compliance with IVIG was observed in 61 (71.8%) patients. The median number of infections per patient in the past year was 3 (IQR = 1-7.5), and 18 (21.2%) patients had no chronic comorbidities. The average total HRQoL score was 69.46 (SD: 18.27), with the lowest subscale score in school functioning (55.61, SD: 19.98, P < 0.001). Social functioning scores were significantly higher than emotional functioning scores (P = 0.023). Multiple regression analysis revealed that poor treatment compliance (P = 0.001), chronic arthritis (P = 0.018), and chronic digestive disorders (P = 0.028) were significantly associated with lower HRQoL.
Conclusions
The HRQoL of children with PAD in mainland China is suboptimal. Enhancing treatment compliance and addressing chronic complications are critical for improving their quality of life. Comprehensive interventions involving social support, medical care, and psychological support are essential.