Systems Human Immunology and AI - Immune Setpoint and Immune Health
Location: Salons H-K
Speaker: John S. Tsang, PhD – Yale Center for Systems and Engineering Immunology (CSEI) and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06510, USA
Evidence for Human Thymopoiesis in a Porcine Thymus Graft and T Cell Tolerance to the Source Pig in a Living Human Recipient of a Porcine GalSafe™ Thymokidney Xenotransplant
Location: Salons F-G
Presenting Author: Farshid Fathi, Dr – Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA
Basic Science of Immunology - Adaptive Immunity
3:45pm – 4:00pm East Coast USA Time
Mechanistic Studies in a New Tolerance Trial of Combined Kidney and Bone Marrow Transplantation
Daratumumab Depletes Pathogenic Antibody-Secreting Cells, Reduces Type-I Interferon Activity and Improves T Cell Function in Systemic Lupus Erythematosus
A New Risk Gene Is Associated with Very Early Onset Inflammatory Bowel Disease and Autoimmune Hepatobiliary Disease: A Mechanistic Study Using Patient Organoids and Transgenic Models
Therapeutic Development for Axial Spondyloarthritis: ERAP-1 Inhibition by GRWD0715 Results in Auto-Antigen Loss on HLA-B*27 and the Inhibition of Cognate CD8⁺ T Cell Responses
Single-Cell Multi-Omic Profiling of Human Influenza Challenge Uncovers Dynamic Peripheral Innate Responses Modulated by Disease Severity and Viral Shedding
Friend or Foe? Tissue Resident Memory CD8+ T Cells with Patient Specific TCRs Induce Allopurinol Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Location: Salons H-K
Presenting Author: Chelsea N. Campbell, MS – Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
Allergy
2:50pm – 3:15pm East Coast USA Time
Heterogeneity of Type 2 Immune Response in Rewilded Mice
Chronic Exposure to Glyphosate-Based Herbicides Compromises Semen Quality, Which in Turn Disrupts the Immunoregulation of the Female Genital Tract and Affects Fetal Development
Blood Drivers of Thromboinflammation and Neuropathology in COVID-19
Location: Salons F-G
Speaker: Katerina Akassoglou, PhD – Gladstone Institutes, University of California - San Francisco
2:35pm – 2:50pm East Coast USA Time
Beyond Genetics: Lyme Disease's Unexpected Role in Connective Tissue Health - Findings from a Murine Model for Borrelia Burgdorferi Infection and the Human Clinical Study MAESTRO
TGF-β3 Induces Oral Tolerance by Imprinting Gut-Homing Capacity in Regulatory T Cells
Location: Salons H-K
Presenting Author: Diego Delgado-Zaldívar – INCMNSZ – National Institute of Medical Sciences and Nutrition Salvador Zubirán
Mucosal Immunology
4:55pm – 5:10pm East Coast USA Time
Stimulated CD4+ T Cells Initiate Blood Coagulation Through Polyphosphate Release
Location: Salons H-K
Presenting Author: Reiner K. Mailer, n/a – University Medical Center Hamburg-Eppendorf
Basic Science of Immunology - Adaptive Immunity
5:10pm – 5:25pm East Coast USA Time
Lymph Node HIV-specific CD8 T Cells of HIV Controllers Harbour a Specific Transcriptomic Signature
Location: Salons H-K
Presenting Author: Andrea Mastrangelo – Centre Hospitalier Universitaire Vaudoise
Infectious Diseases
5:25pm – 5:40pm East Coast USA Time
RhoG Is Upregulated in Neutrophils and Monocytes Isolated from Peripheral Blood of Septic Patients and Animals and Regulates Migration and Inflammatory Functions in Innate Immune Cells in Vitro
Combinatorial Genetic Engineering Strategy for Antigen-specific Protection of Stem Cell-derived Beta Cells by Chimeric Antigen Receptor Regulatory T Cells
Engineered Cellular Therapies Targeting 9G4 Idiotope B Cells in Autoimmune Diseases and Lymphoma
Location: Salons F-G
Presenting Author: Jin Liu, n/a – The Johns Hopkins University School of Medicine
Autoimmune Diseases
6:10pm – 6:25pm East Coast USA Time
Chemokine-engineered CAR-T Cells for Autoimmunity: Multiplexed mRNA Technology for Improved Mode of Action and Safety
Location: Salons F-G
Presenting Author: Norman M. Drzeniek, MD PhD – Charité Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, BIH Center for Regenerative Therapies
Implementation of Complex in Vitro 3D Lung Cancer Model to Monitor Resistance to Immune Checkpoint Inhibitors Through Deep Profiling at Single-cell and Spatial Resolution
cDC1 and Tissue-Resident Exhausted CD8 T Cells Drives Disease Control and Checkpoint Blockade Immunotherapy Response in Melanoma
Location: Salons A-D
Presenting Author: Sarai G. De Leon – UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social/Posgrado en Ciencias Biológicas, National Autonomous University of Mexico, Mexico
Immuno-oncology
4:55pm – 5:10pm East Coast USA Time
Single Cell Spatial Transcriptomics of the Human Bone Marrow Reveals Active Adaptive Immunity in Myelodysplastic Syndromes
Location: Salons A-D
Presenting Author: Susan DeWolf, MD – Memorial Sloan Kettering Cancer Center
Co-Chair: Sarai G. De Leon – UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social/Posgrado en Ciencias Biológicas, National Autonomous University of Mexico, Mexico
Co-Chair: Sarai G. De Leon – UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social/Posgrado en Ciencias Biológicas, National Autonomous University of Mexico, Mexico
10:00am – 10:30am East Coast USA Time
Precision Medicine for Immune Dysregulation - Title Coming Soon