Evidence for Human Thymopoiesis in a Porcine Thymus Graft and T Cell Tolerance to the Source Pig in a Living Human Recipient of a Porcine GalSafe™ Thymokidney Xenotransplant
Daratumumab Depletes Pathogenic Antibody-Secreting Cells, Reduces Type-I Interferon Activity and Improves T Cell Function in Systemic Lupus Erythematosus
A New Risk Gene Is Associated with Very Early Onset Inflammatory Bowel Disease and Autoimmune Hepatobiliary Disease: A Mechanistic Study Using Patient Organoids and Transgenic Models
Location: Salons A-D
Presenting Author: Siyan Cao, MD, PhD – Washington University in St. Louis
Autoimmune Diseases
3:30pm - 3:45pm East Coast USA Time
The Ulcerative Colitis Susceptibility Gene Adenylyl Cyclase 7 Restrains Th2 Cytokine Production and Class II Antigen Presentation
Therapeutic Development for Axial Spondyloarthritis: ERAP-1 Inhibition by GRWD0715 Results in Auto-Antigen Loss on HLA-B*27 and the Inhibition of Cognate CD8⁺ T Cell Responses
Single-Cell Multi-Omic Profiling of Human Influenza Challenge Uncovers Dynamic Peripheral Innate Responses Modulated by Disease Severity and Viral Shedding
Friend or Foe? Tissue Resident Memory CD8+ T Cells with Patient Specific TCRs Induce Allopurinol Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Chronic Exposure to Glyphosate-Based Herbicides Compromises Semen Quality, Which in Turn Disrupts the Immunoregulation of the Female Genital Tract and Affects Fetal Development
Blood Drivers of Thromboinflammation and Neuropathology in COVID-19
Location: Salons F-G
Speaker: Katerina Akassoglou, PhD – Gladstone Institutes, University of California - San Francisco
2:35pm - 2:50pm East Coast USA Time
Beyond Genetics: Lyme Disease's Unexpected Role in Connective Tissue Health - Findings from a Murine Model for Borrelia Burgdorferi Infection and the Human Clinical Study MAESTRO
Location: Salons F-G
Presenting Author: Grace Loeser, BSc – Massachusetts Institute of Technology
Infectious Diseases
2:50pm - 3:15pm East Coast USA Time
Vaccine Immunity Counteracts Respiratory Virus-mediated Impairment of Immunological and Neurological Synapses
Location: Salons F-G
Speaker: Alexis M. Kalergis, PhD – Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile
3:15pm - 3:30pm East Coast USA Time
Germline Variants and Somatic Mosaic Chromosomal Alterations Affect COVID-19 Vaccine Immunogenicity, Infectious Diseases, and Autoimmune Diseases
Location: Salons F-G
Presenting Author: Yukinori Okada, MD, PhD – The University of Tokyo, Osaka University, RIKEN IMS
Immunogenetics
3:30pm - 3:55pm East Coast USA Time
What Triggers Multisystem Inflammatory Syndrome in Children after SARS-CoV-2 Infection?
RhoG Is Upregulated in Neutrophils and Monocytes Isolated from Peripheral Blood of Septic Patients and Animals and Regulates Migration and Inflammatory Functions in Innate Immune Cells in Vitro
Combinatorial Genetic Engineering Strategy for Antigen-specific Protection of Stem Cell-derived Beta Cells by Chimeric Antigen Receptor Regulatory T Cells
Implementation of Complex in Vitro 3D Lung Cancer Model to Monitor Resistance to Immune Checkpoint Inhibitors Through Deep Profiling at Single-cell and Spatial Resolution
cDC1 and Tissue-Resident Exhausted CD8 T Cells Drives Disease Control and Checkpoint Blockade Immunotherapy Response in Melanoma
Location: Salons A-D
Presenting Author: Sarai G. De Leon Rodríguez, MD – UMAE Specialty Hospital, National Medical Center “Siglo XXI,” Mexican Social Security Institute (IMSS) / Graduate Program in Biological Sciences, National Autonomous University of Mexico (UNAM)
Immuno-oncology
4:55pm - 5:10pm East Coast USA Time
Single Cell Spatial Transcriptomics of the Human Bone Marrow Reveals Active Adaptive Immunity in Myelodysplastic Syndromes
Location: Salons A-D
Presenting Author: Susan DeWolf, MD – Memorial Sloan Kettering Cancer Center
Co-Chair: Sarai G. De Leon Rodríguez, MD – UMAE Specialty Hospital, National Medical Center “Siglo XXI,” Mexican Social Security Institute (IMSS) / Graduate Program in Biological Sciences, National Autonomous University of Mexico (UNAM)
Co-Chair: Sarai G. De Leon Rodríguez, MD – UMAE Specialty Hospital, National Medical Center “Siglo XXI,” Mexican Social Security Institute (IMSS) / Graduate Program in Biological Sciences, National Autonomous University of Mexico (UNAM)